Statin Drugs - Inhibits The Enzyme HMG-CoA Reductase

Statins are the class of drugs which helps in lowering the cholesterol levels. They are also called as HMG-CoA reductases inhibitors, as it inhibits the enzyme HMG-CoA reductase. HMG-CoA reductase is the rate-limiting enzyme of the mevalonate pathway of cholesterol synthesis.

Statins have the similar molecular properties as that of the enzyme HMG-CoA reductase. This enzyme is the first committed enzyme in the production of cholesterol in the cholesterol synthesis pathway. These enzymes produce mevalonate in the next step of the pathway, which is the next molecule in the cascade which finally leads to the synthesis of cholesterol and other byproducts.

When statins inhibit the HMG-CoA reductase and takes it place as it is similar in molecular level, the synthesis of cholesterol is stopped due to the unavailability of HMG-CoA reductase enzyme.  Thus it helps in controlling the levels of cholesterol.  As most of the cholesterol is formed only from the internal synthesis than the diet, this process is very efficient in controlling cholesterol synthesis.

When the liver is unable to produce cholesterol any longer, the blood cholesterol level also drops. Statin acts faster in the night as the cholesterol synthesis mostly occurs at night during sleep. Statin also has great role in the prevention of cardiovascular diseases. It improves endothelial function and modulates the inflammatory responses.

It helps in maintaining the plaque stability and prevents the heart from thrombus formation. Those who have high cholesterol are best benefitted by statin drugs. Statin is the generic name and Atorvastatin, rosuvastatin, pravastatin, lovastatin, and fluvastatin are from the classes of Statin Drugs.  Generic Statins are available in an online pharmacy.

It is not just sufficient to be on drugs.  Several work ups and revision in life style are important.  Specifically, a revamp of your entire diet pattern is warranted! It is health – the best thing of all and you need to do several things to be in shape.